교수진

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교수진소개

교수정보의 상세 화면
박대찬
이름
박대찬
학력
박사
전공
생명과학전공(과)
정보
연구실 :
원천관203

연구실번호 :
2514

이메일 :
dpark@ajou.ac.kr

연구관심분야 :
Genomics, Bioinformatics, Computational Biology, Immune Repertoire

홈페이지 :
학력
졸업연도/학교/학위
2014.05 Univ Texas-Austin 박사
졸업연도/학교/학위
2008.02 서울대학교 학사
경력 2018 - 현재 아주대학교 조교수
2016 - 2018 한국과학기술연구원 (KIST) 선임연구원
2014 - 2016 University of Texas at Austin 화학공학과 박사후연구원
논문 및 연구활동
연구활동(주요논문)
  • [논문] 박대찬, Hidetaka Tanno, Timothy M. Gould, Jonathan R. McDaniel, Wenqiang Cao, Yuri Tanno, Jörg J. Goronzy, Steven J. Cate, William H. Hildebrand, Cornelia L. Dekker, Lu Tian, Cornelia M. Weyand, George Georgiou, Russell E. Durrett, Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , Vol.1 , No.117 , pp.532 -540 (Jan, 2020)
  • [논문] 김용성, 백두산, 조병철, 박대찬, 강한나, 김예진, 이세영, Dual-targeting of EGFR and Neuropilin-1 attenuates resistance to EGFRtargeted antibody therapy in KRAS-mutant non-small cell lung cancer , CANCER LETTERS , pp.23 -34 (Dec, 2019)
  • [논문] 박대찬, Anna M Battenhouse, Vishwanath R Iyer, Dia N Bagchi, The histone variant H2A.Z in yeast is almost exclusively incorporated into the +1 nucleosome in thedirection of transcription , NUCLEIC ACIDS RESEARCH , pp.1 -14 (Nov, 2019)
  • [논문] 박대찬, 김동하, 김경규, 부경진, 유영석, 김익수, 전윤, 임선경, 이수형, 이지민, 고연희, 이호, 황성순, 백성희, 오세규, RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , Vol.116 , No.42 , pp.21140 -21149 (Oct, 2019)
  • [논문] 박대찬, 김다은, Deep sequencing of B cell receptor repertoire , BMB REPORTS , Vol.52 , No.9 , pp.540 -547 (Sep, 2019)
국제학술논문지
  • [논문] 박대찬, Hidetaka Tanno, Timothy M. Gould, Jonathan R. McDaniel, Wenqiang Cao, Yuri Tanno, Jörg J. Goronzy, Steven J. Cate, William H. Hildebrand, Cornelia L. Dekker, Lu Tian, Cornelia M. Weyand, George Georgiou, Russell E. Durrett, Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , Vol.1 , No.117 , pp.532 -540 (Jan, 2020)
  • [논문] 김용성, 백두산, 조병철, 박대찬, 강한나, 김예진, 이세영, Dual-targeting of EGFR and Neuropilin-1 attenuates resistance to EGFRtargeted antibody therapy in KRAS-mutant non-small cell lung cancer , CANCER LETTERS , pp.23 -34 (Dec, 2019)
  • [논문] 박대찬, Anna M Battenhouse, Vishwanath R Iyer, Dia N Bagchi, The histone variant H2A.Z in yeast is almost exclusively incorporated into the +1 nucleosome in thedirection of transcription , NUCLEIC ACIDS RESEARCH , pp.1 -14 (Nov, 2019)
  • [논문] 박대찬, 김동하, 김경규, 부경진, 유영석, 김익수, 전윤, 임선경, 이수형, 이지민, 고연희, 이호, 황성순, 백성희, 오세규, RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , Vol.116 , No.42 , pp.21140 -21149 (Oct, 2019)
  • [논문] 박대찬, 김다은, Deep sequencing of B cell receptor repertoire , BMB REPORTS , Vol.52 , No.9 , pp.540 -547 (Sep, 2019)
  • [논문] 이종수, 강미애, 백철준, 이예진, 박대찬, 김병규, 명경재, 정재훈, 한주석, 황순영, Ngo Thanh Hang, CTCF cooperates with CtIP to drive homologousrecombination repair of double-strand breaks , NUCLEIC ACIDS RESEARCH , Vol.9 , No.9 , pp.1 -20 (Jul, 2019)
  • [논문] 박대찬, Xingyu Yang, Shaza Abnouf, Jay R. T. Adolacion, Sanam Soomro, Jason Roszik, Cristian Coarfa, Gabrielle Romain, Keith Wanzeck, S. Louis Bridges Jr., Amita Aggarwal, Peng Qiu, Sandeep K. Agarwal, Chandra Mohan, Navin Varadarajan, Ankit Mahendra, Beyond autoantibodies: Biological roles of human autoreactive B cells in rheumatoid arthritis revealed by RNA‐sequencing , ARTHRITIS & RHEUMATOLOGY , Vol.71 , No.4 , pp.529 -541 (Apr, 2019)
  • [논문] 박대찬, 신찬석, 김종헌, 이두영, 박준현, Poly(A)-specific ribonuclease sculpts the 3′ ends of microRNAs , RNA-A PUBLICATION OF THE RNA SOCIETY , Vol.25 , No.3 , pp.388 -405 (Mar, 2019)
  • [논문] 박대찬, Andrew D. Ellington, 정철희, Selection of self-priming molecular replicators , NUCLEIC ACIDS RESEARCH , Vol.47 , No.5 , pp.2169 -2176 (Jan, 2019)
  • [논문] Vishwanath R. Iyer, 박대찬, Yaelim Lee, The ATP-dependent chromatin remodeler Chd1 is recruited by transcription elongation factors and maintains H3K4me3/H3K36me3 domains at actively transcribed and spliced genes , NUCLEIC ACIDS RESEARCH , pp.7180 -7190 (Jul, 2017)
  • [논문] George Georgiou, Daniel R Boutz, Veronika Chromikova, M Gordon Joyce, Christopher Vollmers, Kwanyee Leung, Andrew P Horton, Brandon J DeKosky, Chang-Han Lee, Jason J Lavinder, Ellen M Murrin, Constantine Chrysostomou, Kam Hon Hoi, Yaroslav Tsybovsky, Paul V Thomas, Aliaksandr Druz, Baoshan Zhang, Yi Zhang, Lingshu Wang, Wing-Pui Kong, Lyubov I Popova, Cornelia L Dekker, Mark M Davis, Chalise E Carter, Ted M Ross, Andrew D Ellington, Patrick C Wilson, Edward M Marcotte, John R Mascola, Gregory C Ippolito, Florian Krammer, Stephen R Quake, Peter D Kwong, 박대찬, Jiwon Lee, Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination , NATURE MEDICINE , pp.1456 -1464 (Dec, 2016)
  • [논문] George Georgiou, Brandon J. DeKosky, Oana I. Lungu, Erik L. Johnson, Wissam Charab, Daisuke Kuroda, Andrew D. Ellington, Gregory C. Ippolito, Jeffrey J. Gray, 박대찬, Constantine Chrysostomou, Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (May, 2016)
  • [논문] Dean G. Tang, Yi Zhong, Yue Lu, Kiera Rycaj, Shuai Gong, Xin Chen, Xin Liu, Hsueh-Ping Chao, Pamela Whitney, Tammy Calhoun-Davis, Yoko Takata, Jianjun Shen, Vishwanath R. Iyer, 박대찬, Dingxiao Zhang, Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer , NATURE COMMUNICATIONS , pp.10798 -10798 (Feb, 2016)
  • [논문] Haley O. Tucker, Joseph D. Dekker, Arthur L. Shaffer, Holger Kohlhammer, Wei Deng, Gregory C. Ippolito, George Georgiou, Vishwanath R. Iyer, Louis M. Staudt, 박대찬, Bum-Kyu Lee, Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1 , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (Feb, 2016)
  • [논문] Vishwanath R. Iyer, 박대찬, Haridha Shivram, Chd1 co-localizes with early transcription elongation factors independently of H3K36 methylation and releases stalled RNA polymerase II at introns , EPIGENETICS & CHROMATIN , pp.32 -32 (Oct, 2014)
  • [논문] Lauren I.R. Ehrlich, Sanghee Ki, Hilary J. Selden, Haewon Chung, Jonghwan Kim, Vishwanath R. Iyer, 박대찬, Jun Seita, Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution , CELL REPORTS , pp.402 -415 (Oct, 2014)
  • [논문] Vishwanath R. Iyer, Anna Battenhouse, 박대찬, Adam R. Morris, Simultaneous mapping of transcript ends at single-nucleotide resolution and identification of widespread promoter-associated non-coding RNA governed by TATA elements , NUCLEIC ACIDS RESEARCH , Vol.42 , No.6 , pp.3736 -3749 (Apr, 2014)
  • [논문] Vishwanath R. Iyer, Gurvani Bhupindersingh, 박대찬, Yaelim Lee, Widespread misinterpretable ChIP-seq bias in yeast , PLoS ONE , Vol.8 , No.12 , pp.1 -16 (Dec, 2013)
  • [논문] Junho Lee, Moon Cheol Park, Taesung Park, 박대찬, Eun-Kyung Lee, Genomic analysis of the telomeric length effect on organismic lifespan in Caenorhabditis elegans , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , pp.382 -387 (May, 2010)
국제학술발표
  • [학술회의] 박대찬, Selection of self-priming molecular replicators , The International Conference of the Genetics Society of Korea 2019 (ICGSK 2019) (Nov, 2019)
  • [학술회의] 박대찬, Genomic analysis of self-growing DNA in molecular evolution system , The 15th International Conference on Bioinformatics (BIOINFO 2019) (Aug, 2019)
  • [학술회의] 박대찬, Deep Sequencing of the Antibody Repertoire , International Congress of ORL-HNS 2018 및 제92차 대한이비인후과학회 학술대회 및 2018년 춘계 대한이비인후과의사회 학술대회 (Apr, 2018)
국내학술발표
  • [학술회의] 박대찬, Repertoire analysis of human autoreactive B cells in rheumatoid arthritis by deep sequencing , 2018 한국 항체 소사이어티 하계 워크샵 (Jul, 2018)
  • [학술회의] 박대찬, 백신에 의해 유도된 항체 레파토리에 대한 유전단백체 분석 , 한국공업화학회 춘계학술대회 (May, 2018)
특허 및 기타
  • [특허] 박대찬, 황성순, 오세규, 백성희, 김동하, 알오알알파를 표적으로 하는 염증성 장질환 치료제 스크리닝 방법 (출원) (PCT/KR2019/016833) (Dec, 2019)
  • [특허] 박대찬, 황성순, 김동하, 백성희, 오세규, RORα를 표적으로 하는 염증성 장질환 치료제 스크리닝 방법 (출원) (10-2019-0140915) (Nov, 2019)
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