교수진

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교수진소개

교수정보의 상세 화면
이종수
이름
이종수
학력
박사
전공
생명과학전공(과)
정보
연구실 :
원천관 206

연구실번호 :
1886

이메일 :
jsjlee@ajou.ac.kr

연구관심분야 :
유전체안정성, 암생물학, 후성유전체학

홈페이지 :
.
학력
졸업연도/학교/학위
1994.08 서울대학교 박사
졸업연도/학교/학위
1985.02 서울대학교 학사
경력 1994. 09    1995. 01    서울대학교 분자미생물우수연구센터 박사후연수
1995. 01    2000. 02    미국 NIH    Research Fellow
2000. 03    2001. 02    한양대학교 BK 조교수
2001. 03    2005. 02    국립암센터 책임연구관
2005.3    현재    아주대학교 자연과학대학 교수
연구분야 본 연구실은 암 및 노화와 관련하여 크로마틴 architecture 조절과, 종양 미세환경에서의 DNA 손상반응과 후성유전적 조절 작용과 기전을 규명하는 연구를 한다. 현재 주요 연구분야는 아래와 같다.

1) 크로마틴 단백질에 의한 유사분열 진행 조절의 분자기전
유사분열은 핵 내의 염색체를 두 쌍의 딸세포로 동일하게 분리하는 과정을 일컫는다. 유사분열 동안 Chromosome Passenger Complex (CPC)는 크로마틴 정렬을 비롯하여, 히스톤 modification 및 세포질 분열 등을 포괄적으로 조절한다. 유사분열이 진행되는 동안 CPC는 정확한 시기에 따라 역동적으로 그 위치 및 활성을 달리하여 그 기능을 다한다. 본 연구실에서는 알려진 CPC 구성원 이외에 새로운 단백질을 발굴하여 CPC의 위치와 기능 및 유사분열을 조절하는 Mechanism에 관해 연구한다.

2) 크로마틴 단백질에 의한 DNA 손상신호 mediator의 DNA 손상 복구-전사 통합조절 연구
우리 인간을 비롯한 모든 생명체는 외부 및 내부의 DNA 손상신호에 항상 노출 되어 있다. 손상된 DNA가 수선되지 않는다면 돌연변이가 유발되고, 암과 같은 질병에 걸리게 된다. DNA 이중나선 손상을 수선하는 두 가지 주요 경로는 Non-Homologous End Joining (NHEJ)과 Homologous Recombination (HR) 이다. NHEJ는 본질적으로 오류가 발생하기 쉬운 반면 HR에 의한 DNA 수선은 상동 DNA 서열을 이용 오류 없이 일어나게 된다. HR에 의한 DNA 이중나선 손상 수선 경로는 상동 DNA 서열이 존재하는 즉, S/G2 세포주기에 활성이 증가되어 있는 반면, NHEJ는 세포주기 전반에 걸쳐 일어날 수 있다. 본 연구실에서는 HR 과 NHEJ사이 수선 경로를 결정 지을 수 있는 후보 단백질을 발굴하여, 이 단백질이 어떻게 두 수선 경로 중 하나를 결정하고 수선할 수 있는지 연구한다.  

3) 종양 미세환경에서의 후성유전적 조절 연구
종양 미세환경은 종양 세포와 그 주변의 정상 세포군, 세포외기질 (Extra-cellular matrix) 및 체액이 구성하는 복합적인 상태를 생태학적 환경에 비유함을 지칭한다. 일반적으로, 종양 미세환경은 저산소, 저영양화되어 있으며, 종양 세포 및 주변 정상 세포, 면역 세포들의 상호 신호 전달이 항진되어 있다. 특히 종양 세포는 선천적 유전적 변화 외에, 주변 정상 세포군들과의 상호 신호전달을 통한 후성 유전적 변화 (Epigenetical change)에 의해 암화 증대, 전이 및 주변 세포질로의 침윤등이 조절된다. 본 연구실은 이러한 종양 세포와 주변 정상 세포간의 상호 신호 전달에 의한 후성 유전적 변화를 분석하고, 심화 연구를 진행함으로서 기존 항암 치료의 효율을 증대시킬 수 있는 기초적 지식을 제공하고 있다.    

4) 역동적인 크로마틴 구조를 형성/유지하는 히스톤 변형체들의 DNA 손상 부위에서의 역할 규명
유전자 손상 관련 히스톤 variant (H2AX, H3.3), 크로마틴 리모델링, 히스톤 수식화에 의한 크로마틴 동력성의 조절은 DNA 복구와 복구완료 이후의 복원(post-repair recovery)에 관여하는 인자들의 DNA로의 인식/접근/결합을 조절함으로써, 복구/복원 과정의 핵심적인 중요한 기전으로 작용한다. 본 연구실은 유전자 손상 관련 히스톤 variant 및 수직화에 의한 크로마틴 리모델링 및 DNA 손상 복구-전사의 통합적 조절에 관한 연구를 진행하고 있다. 
기타 5) 대사작용과 후성유전체 조절에 의한 암화•노화 결정 기전을 연구하기 위하여, Clock(낮과 밤, 식사등을 포함하는 바이오 리듬 조절)에 의한 후성유전체 및 DNA 손상 반응 조절 연구를 시작.
논문 및 연구활동
연구활동(주요논문)
  • [논문] FIP200 INHIBITS β-CATENIN-MEDIATED TRANSCRIPTION BY PROMOTING APC-INDEPENDENT β-CATENIN UBIQUITINATION (ONCOGENE) - 2013.05
    이종수, 정가진, 박미애, 최재덕, 류민숙
  • [논문] Suppression and recovery of BRCA1-mediated transcription by HP1gamma via moulation of promoter occupancy (NUCLEIC ACIDS RESEARCH) - 2012.12
    이종수, 박미애, 최재덕
  • [논문] A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with funcitonal mismatch repair via a p38-depedent pathway (JOURNAL OF BIOLOGICAL CHEMISTRY) - 2010.01
    장은령, 송기원, 김정호, 류민숙, 박정은, 이종수
  • [논문] SUMO1 NEGATIVELY REGULATES BRCA1-MEDIATED TRANSCRIPTION, VIA MODULATION OF PROMOTER OCCUPANCY (Nucleic Acids Research) - 2007.12
    이종수, 정가진, 박미애, 석영재
  • [논문] MethylCpG-binding domain protein 3 mediates cancer-selective cytotoxicity by HDAC inhibitors via differential transcriptional reprogramming in lung cancer cells (Cancer Research) - 2005.12
    이종수, 장은령, 정가진, 노은주, 민철기, 이유미
국제학술논문지
  • [논문] FIP200 INHIBITS β-CATENIN-MEDIATED TRANSCRIPTION BY PROMOTING APC-INDEPENDENT β-CATENIN UBIQUITINATION (ONCOGENE) - 2013.05
    이종수, 정가진, 박미애, 최재덕, 류민숙
  • [논문] Suppression and recovery of BRCA1-mediated transcription by HP1gamma via moulation of promoter occupancy (NUCLEIC ACIDS RESEARCH) - 2012.12
    이종수, 박미애, 최재덕
  • [논문] AuroraB confers cancer cell resistnace to TRAIL-induced apoptosis via phosphorylation of survivin (CARCINOGENESIS) - 2012.03
    최경숙, 윤미진, 박석순, 이주안, 김인영, 이창우, 김은진, 이종수, 강유정
  • [논문] Resistnace to palitaxel in hepatoma cells is related to static JNK activation and prohibition into entry of mitosis (AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY) - 2012.02
    조혜성, 김영배, 이종수, 채선영
  • [논문] Atmospheric-Pressure Plasma Jet Induces Apoptosis Involving Mitochondria via Generation of Free Radicals (PLoS ONE) - 2011.11
    이종수, 문은표, 김강일, 김근영, 양상식, 안학준
  • [논문] Atmospheric-pressure plasma-jet from micronozzle array and its biological effects on living cells for cancer therapy (APPLIED PHYSICS LETTERS) - 2011.02
    양상식, 최재덕, 이종수, 김근영, 노은주, 김강일, 홍영철
  • [논문] Acetyltransferase p300 regulates NBS1-mediated DNA damage response (Febs letters) - 2011.01
    이종수, 장은령, 최재덕
  • [논문] Phosphorylation of p300 by ATM controls the stability of NBS1 (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS) - 2010.07
    이종수, 최재덕, 정가진, 장은령
  • [논문] ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response (EXPERIMENTAL AND MOLECULAR MEDICINE) - 2010.03
    이종수, 정가진, 박미애, 조혜성, 장은령, 최재덕
  • [논문] A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with funcitonal mismatch repair via a p38-depedent pathway (JOURNAL OF BIOLOGICAL CHEMISTRY) - 2010.01
    장은령, 송기원, 김정호, 류민숙, 박정은, 이종수
  • [논문] Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules (JOURNAL OF ETHNOPHARMACOLOGY) - 2009.11
    전미선, 강승희, 정가진, 심범상, 유영법, 이종수, 김은혜
  • [논문] An HDAC inhibitor, Trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-depedent manner (Biochemical and Biophysical Research Communications) - 2009.01
    이종수, 정가진, 노은주, 임대식
  • [논문] A Novel Role for Methyl CpG-Binding Domain Protein 3, a Component of the Histone Deacetylase Complex, In Regulation of Cell Cycle Progression and Cell Death (Biochemical and Biophysical Research Communications) - 2009.01
    이종수, 노은주, 임대식
  • [논문] Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk (Journal of Ethnopharmacology) - 2008.02
    이종수, 정가진, 심범상, 유영범, 류민숙, 김은혜
  • [논문] Low energy proton beam induces tumor cell apoptosis through reactive oxygen species and activation of caspases (EXPERIMENTAL and MOLECULAR MEDICINE) - 2008.02
    이종수, You Mie Lee, Tae-Lin Huh, Jin-Woo Park, Kheun Byeol Lee
  • [논문] SUMO1 NEGATIVELY REGULATES BRCA1-MEDIATED TRANSCRIPTION, VIA MODULATION OF PROMOTER OCCUPANCY (Nucleic Acids Research) - 2007.12
    이종수, 정가진, 박미애, 석영재
  • [논문] Syndecan-1, a key regulator of cell viability in endoemtrial cancer (International Journal of Cancer) - 2007.04
    민철기, 이종수, 김현창, 김지혜, 최동순, 유희석, 한재호
  • [논문] Methyl CpG-Binding Domain Protein 3 mediates cancer-selective cytotoxicity by histone deacetylase inhibitors via differential transcriptional reprogramming in lung cance cells (Cancer Research) - 2005.12
    이종수, 장은령, 노은주, 이유미, 정가진
  • [논문] MethylCpG-binding domain protein 3 mediates cancer-selective cytotoxicity by HDAC inhibitors via differential transcriptional reprogramming in lung cancer cells (Cancer Research) - 2005.12
    이종수, 장은령, 정가진, 노은주, 민철기, 이유미
  • [논문] Sodium butyrate sensitizes human glioma cells to TRAIL-mediated apoptosis through inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP (Oncogene (Nature publishing group)) - 2005.10
    이종수, 김희수, 김은희, 김승유, 노은주
  • [논문] SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification (EMBO reports) - 2005.10
    김은희, 장문선, 이윤석, 이종수, 최의주
국내학술논문지
  • [논문] Activation of ATM-Dependent DNA Damage Signal Pathway by a Histone deacetylase Inhibitor, Trichostatin A (Cancer Research and Treatment) - 2007.12
    이종수
  • [논문] Functional link between DNA damage responses and transcriptional regulation by ATM in response to a histone deacetylase inhibitor, TSA (Cancer Research and Treatment) - 2007.12
    이종수
국제학술발표
  • [학술회의] Generation of ROS by Air Plasma-jet on Living Cancer Cell and Its Underlying Molecular Mechanisms (The 4th International Conference on Microelectronics and Plasma Technology) - 2012.07
    양상식, 이종수, 조민욱, 김강일, 안학준
  • [학술회의] The Effects of Air and Nitrogen Plasma Jets on Living Cancer Cells (4th International Conference on Plasma Medicine) - 2012.06
    양상식, 이종수, 조민욱, 김강일, 안학준
  • [학술회의] Downregulation of BRCA1-mediated transcription by HP1 via modulation of promoter occupancy (Asian Conference on Transcription) - 2012.06
    이종수, 최재덕
  • [학술회의] Regulation of beta catenin-mediated transcriptionby FIP200 via promoting APC-indepedent beta-catenin ubiquitination (Asian Conference on Transcription) - 2012.06
    이종수, 최재덕, 정가진
  • [학술회의] Effect of Atmospheric-Pressure Plasma-jet on Living Cancer Cell and Its Underlying Molecular Mechanisms (The 3rd International Conference on Microelectronics and Plasma Technology) - 2011.07
    양상식, 이종수, 김근영, 김강일, 안학준
  • [학술회의] THE ROS EFFECT OF ATMOSPHERIC-PRESSURE PLASMA JET ON CANCER CELL (The 6th International Conference on Microtechnologies in Medicine and Biology) - 2011.05
    양상식, 김근영, 안학준, 이종수, 김강일
  • [학술회의] Atmospheric Plasma Jet from a Micro Nozzle Array and Its Biological Effects on Living Cells for Cancer Therapy (IEEE Sensors 2010 Conference) - 2010.11
    양상식, 김근영, 이종수, 김강일, 최재덕
  • [학술회의] SUMO in BRCA1-mediated DNA damage response (2010년도 한국분자세포생물학회 정기학술대회) - 2010.10
    이종수
  • [학술회의] Atmospheric cold plasma-jet for cancer therapy (The 5th Asia-Pacific Conference on Transducers and Micro-Nano Technology) - 2010.07
    양상식, 최재덕, 이종수, 최기선, 홍영철, 김강일, 김근영
  • [학술회의] HP1 and G9a couple chromatin remodeling that negatively regulates BRCA1-mediated transcription (한국분자세포생물학회) - 2009.10
    이종수, 조현석, 최재덕, 박미애
  • [학술회의] Methyl CpG-Binding Domain Protein 3 Regulates the Progression of Cell Cycle and Cell Death in Cancer Cells (한국 분자 세포생물학회) - 2009.10
    이종수, 허광래, 노은주
  • [학술회의] FIP200 inhibits beta-catenin-mediated transcrtipion via promoting APC-indepedent beta-catenin ubiquitination (한국분자세포생물학회) - 2009.10
    이종수, 류민숙, 정가진, 박미애, 최재덕
  • [학술회의] A novel function of HP1, a Chromatin protein, in mitotic progression and chromosome segregation (해당사항 없음 (Epigenetics)) - 2009.08
    이종수
  • [학술회의] A novel function of HP1, a Chromatin protein, in mitotic progression and chromosome segregation (Cell growth and proliferation) - 2009.07
    이종수
  • [학술회의] Heterochromatin Protein 1-mediated Chromatin Remodeling in Response to DNA damage (International Congress on Cell Biology/ 한국분자세포생물학회) - 2008.10
    이종수, 조현석, 최재덕, 박미애, 오성택
  • [학술회의] A Novel Function of HP1, a Chromatin Protein, in Mitotic Progression and Chromosme Segregation (International Congress on Cell Biology) - 2008.10
    이종수, 박미애
  • [학술회의] Phosphorylation of p300 by ATM controls the atability of NBS1 in response to DNA damage (Radiation Oncology) - 2008.01
    이종수, 류민숙
  • [학술회의] A new isoquinolinium Cadein1 selectively induces apoptosis in cancer cells, vai p38-dependent pathway (Korean Society of Cancer Prevention) - 2007.12
    이종수, 조현석, 임은영, 류민숙, 송기원
  • [학술회의] SUMO-1 negatively regulates tumor suppressive functions of BRCA1 (The 32nd Annual Meeting) - 2006.06
    이종수, 박미애
  • [학술회의] MBD3 mediates cancer-selective cytotoxicity by HDAC inhibitors via differential transcriptional reprogramming in lung cancer cells (The 32nd Annual Meeting) - 2006.06
    이종수, 노은주
  • [학술회의] SUMO-1 negatively regulates BRCA1-mediated transcription (Cancer Models & Mechanisms) - 2005.07
    이종수, 박미애
  • [학술회의] MBD proteins potentiate HDAC inhibitor-induced cancer selective cyotoxicity in lung cancer cells (제 2회 국제 유전자치료 심포지엄) - 2005.06
    이종수, 노은주
국내학술발표
  • [학술회의] Altered chromatin structure is linked to genomic instability in cancer (2013 한국분자·세포생물학회 세포주기분과 Cell cycle symposium) - 2013.06
    이종수
  • [학술회의] Role of HP1 in DNA repair and recovery of BRCA1-mediated transcription in respone ro DNA damage (2013 방사선생명과학회 춘계학술대회) - 2013.06
    이종수
  • [학술회의] Crosstalk between Altered chromatin structure and genomic instability in cancer (The 9th KOGO Winter Symposium) - 2013.02
    이종수, 최재덕
  • [학술회의] Recovery of DNA damage-induced BRCA1- mediated transcription via modulating chromatin architecutre (제35차 한국 세포생물학회 동계학술대회) - 2013.01
    이종수, 최재덕
  • [학술회의] Suppression of beta-catenin mediated transcription by FIP200 in an APC- and autophagy-indepedent manner (제35차 한국 세포생물학회 동계학술대회) - 2013.01
    이종수, 최재덕
  • [학술회의] Regulation of mitotic progression by two HP1 phosphorylations (제 35차 세포생물학회 동계 학술대회) - 2013.01
    이종수, 최재덕
  • [학술회의] Atmospheric-pressure Non-thermal Plasma as Cancer Therapeutics (한국분자세포생물학회) - 2012.10
    양상식, 안학준, 김순미, 이종수, 김강일
  • [학술회의] Suppression of beta-catenin mediated transcription by FIP200 in an APC-independent and autophagy-indepedent manner (한국분자세포생물학회 정기학술대회) - 2012.10
    이종수, Nguyen Ngoc Hoan, 최재덕
  • [학술회의] Recovery of DNA damage-induced transcription via modulating chromatin architecture (한국분자세포생물학회 정기학술대회) - 2012.10
    이종수, 최재덕
  • [학술회의] The chromatin protein HP1gamma, a novel regulator of mitotic progression (한국분자세포생물학회 정기학술대회) - 2012.10
    이종수, 조유나, 최재덕, 임명현
  • [학술회의] Perturbed Epigenetic regulation in tumor microenvironment (한국분자세포생물학회 정기학술대회) - 2012.10
    이종수, 전형구, 최유빈, 안학준
  • [학술회의] Hp1 regulates progression of cell cycle and senescence via its dual role in epigenetic reading and writing (2011년도 세포주기분과 3차 Round table discussion) - 2011.11
    이종수
  • [학술회의] HP1gamma downregulates BRCA1-mediated transcription via modulation of promoter occupancy (2011년 한국분자세포생물학회 정기학술대회) - 2011.10
    이종수, 최재덕
  • [학술회의] Epigenetic response to DNA damage, in tumor microenvironment (2011 한국분자세포생물학회 정기학술대회) - 2011.10
    이종수, 안학준
  • [학술회의] DNA damage response in cancer microenvironment (2011 연세 원자력 기초공동연구소 국제 심포지엄) - 2011.10
    이종수, 안학준
  • [학술회의] The FIP200-mediated tumor supression in colon cancer (대한암학회) - 2011.06
    이종수, 최재덕
  • [학술회의] Development of novel cancer therapeutics using atmosphric-pressure plasma jet (대한암학회) - 2011.06
    이종수, 양윤정, 안학준
  • [학술회의] FIP200 negatively regulates beta-catenin activity via promoting APC-indepedent beta-catenin ubiquitination (2010년도 한국분자세포생물학회 정기학술대회) - 2010.10
    이종수, 설민희, 양윤정, 최유빈, 최재덕, 류민숙
  • [학술회의] A novel function of HP1, a Chromatin protein, in mitotic progression and chromosome segregation (기초의학학술대회) - 2009.04
    이종수, 박미애
  • [학술회의] Regulation of PIAS1-mediated transcription by heterochromatin protein 1 gamma (기초의학학술대회) - 2009.04
    이종수, 최재덕
  • [학술회의] Heterochromatin protein 1-mediated chromatin remodling in response to DNA damage (기초의학학술대회) - 2009.04
    이종수, 조현석, 박미애
  • [학술회의] New experimental approaches for gastric research (Consensus conference Gastric cancer/Colorectal cancer) - 2008.10
    이종수
  • [학술회의] Maintaining of centrosomal and chromosomal integrity by HP1 (Cell Cycle Symposium) - 2008.06
    이종수, 박미애
  • [학술회의] Maintaing of centrosomal and chromosomal integrity by HP1 (Cell cycle symposium) - 2008.06
    이종수, 박미애
  • [학술회의] Discovery and Evaluation of Cancer-Selective Therapeutical Targets for Gene Tehrapy (창립총회 및 기념 심포지엄) - 2006.12
    이종수, 박미애, 노은주
저서 및 번역
  • [저서] 신종플루 - 2010.01
    이종수, 정가진
  • [저서] 생명과학 - 2009.03
    홍영남, 김혜선, 남석현, 도수일, 문은표, 민철기, 박상규, 이종수, 최상돈, 강혜순, 고영규, 고용, 권윤의, 김기중, 김영환, 김은수, 김재진, 김정국, 김준, 박선우, 박세호, 박용근, 박우준, 신숙, 신정섭, 안지훈, 안태인, 오승은, 이경호, 이명민, 이봉희, 이태호, 이호정, 장태용, 조면행, 조진원, 이상임, 김한집
  • [저서] 초심자를 위한 Darwin - 2006.12
    이종수, 정이진, 정헌의, 정가진
특허 및 기타
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