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연구실 :
원천관133호

연구실번호 :
2548

이메일 :
sido@ajou.ac.kr

연구관심분야 :
알츠하이머 및 선천면역 관련 당단백질 구조 및 기능, 당생물학

홈페이지 :
학력
졸업연도/학교/학위
1992.07 Univ. of Georgia, Athens 박사
연구분야 본 연구실은 포유류 글라이코믹스(Mammalian cell glycomics) 실험을 진행하고 있는 Functional Glycomics 실험실로서 세포수준 및 분자수준에서 당단백질 Glycoproteins 및 복합당질 Glycoconjugates 의 다양한 기능과 구조를 규명하는 최신연구들을 수행하고 있다. 특별히 인체 선천면역 방어기전에 관련된 당단백질의 기능해석과 암질환 및 알츠하이머와 같은 뇌신경질환에서 당단백질의 작용기전을 규명하고 있다.
DNA와 RNA를 분석하는 분자생물학기술은 물론 PCR 증폭, 동물세포 배양, HPLC 분석, 당단백질 전기영동 및 Western blotting등 다양한 생물학적, 생화학적 기법을 이용하여 인체질환과 관련된 핵심적인 복합당질 분석 및 당단백질 작용점을 분석하는 실험들을 진행하고 있다. 또한 인체질환 관련 당단백질 작용점에 대한 작용기전의 규명을 위해 동물을 이용한 in vivo 준 임상실험도 병행해서 수행하고 있으며 최종 당단백질 작용점을 타겟하는 당의약(Glyco-Drug) 개발을 위한 당의과학 실험을 진행하고 있다.
논문 및 연구활동
연구활동(주요논문)
  • [논문] 도수일, Untamed aspects of OGT and O-GlcNAc functionality: Hyperthermal sensing and NO regulation , Trends in comparative biochemistry and physiology , Vol.16 , pp.1 -8 (Dec, 2012)
  • [논문] 박용일, 추영국, Kim SM, Chun MH, Ha TJ, Choi HN, Jang SJ, Kim SO, 도수일, Chung MJ, Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids , Life Sciences , Vol.90 , No.21-22 , pp.874 -882 (Jun, 2012)
  • [논문] 도수일, 유인현, Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , Vol.408 , No.1 , pp.52 -57 (Apr, 2011)
  • [논문] 유재훈, 현순실, 도수일, 박상은, Selective alpha-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties , BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , Vol.21 , pp.2441 -2444 (Feb, 2011)
  • [논문] Young-Choon Lee, Haw-Young Kwon, Seok-Jo Kim, Sung-Wook Son, Kyoung-Sook Kim, Jai-Heon Lee, 도수일, Cheorl-Ho Kim, Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells , EXPERIMENTAL AND MOLECULAR MEDICINE , Vol.42 , No.12 , pp.849 -855 (Dec, 2010)
국제학술논문지
  • [논문] 도수일, 이기영, 류인현, Aβ-affected pathogenic induction of S-nitrosylation of OGT and identification of Cys-NO linkage triplet , BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS , Vol.1864 , No.5 , pp.609 -621 (Feb, 2016)
  • [논문] 도수일, Untamed aspects of OGT and O-GlcNAc functionality: Hyperthermal sensing and NO regulation , Trends in comparative biochemistry and physiology , Vol.16 , pp.1 -8 (Dec, 2012)
  • [논문] 박용일, 추영국, Kim SM, Chun MH, Ha TJ, Choi HN, Jang SJ, Kim SO, 도수일, Chung MJ, Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids , Life Sciences , Vol.90 , No.21-22 , pp.874 -882 (Jun, 2012)
  • [논문] 도수일, 유인현, Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS , Vol.408 , No.1 , pp.52 -57 (Apr, 2011)
  • [논문] 유재훈, 현순실, 도수일, 박상은, Selective alpha-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties , BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , Vol.21 , pp.2441 -2444 (Feb, 2011)
  • [논문] Young-Choon Lee, Haw-Young Kwon, Seok-Jo Kim, Sung-Wook Son, Kyoung-Sook Kim, Jai-Heon Lee, 도수일, Cheorl-Ho Kim, Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells , EXPERIMENTAL AND MOLECULAR MEDICINE , Vol.42 , No.12 , pp.849 -855 (Dec, 2010)
  • [논문] 도수일, Generation of novel chimeric LacdiNAcS by gene fusion of alpha-lactalbumin and beta1,4-galactosyltransferase 1 , Glycoconjugate Journal , Vol.11 , No.12 , pp.1 -9 (Nov, 2008)
  • [논문] Y.C.Lee, C.H.Kim, N.Y.Kang, H.M.Dae, H.Y.Kwon, 도수일, K.S.Kim, Valproic acid-mediated transcriptional regulation of human GM3 synthase (hST3Gal V) in SK-N-BE(2)-C human neuroblastoma cells , Acta Phamacologica Sinica , Vol.29 , No.9 , pp.999 -1005 (Sep, 2008)
  • [논문] 도수일, 유인현, 신일수, Sp1 modulates ncOGT activity to alter target recognition and enhanced thermotolerance in E. coli , Biochemical and Biophysical Research Communication , Vol.372 , No.1 , pp.203 -209 (May, 2008)
  • [논문] YI Park, SM Kim, YK Choo, WJ Kim, YH Lee, 도수일, JS Lee, Increased alpha-2,3-sialylation and hyperglycosylation of N-glycans in embryomic rat cortical neurons during camptothecin-induced apoptosis , Molecules and Cells , Vol.24 , No.3 , pp.417 -424 (Dec, 2007)
  • [논문] YJ Choo, DH Lee, DB Koo, HJ Yang, SM Kim, JU Jung, JW Jin, KN Ko, KS Ko, KY Jung, 도수일, JS Ryu, Effects of daunorubicin on ganglioside expression and neuronal differentiation of mouse embryonic stem cells , Biochemical and Biophysical Research Communication , Vol.19 , No.362 , pp.313 -318 (Aug, 2007)
  • [논문] SS Lee, EH Alcantara외, DH Kim, 도수일, Bi-functional activities of chimeric lysozymes constructed by domain swapping between bacteriophage T7 and K11 lysozymes , Journal of Biochemistry and Molecular Biology , Vol.40 , No.4 , pp.539 -546 (Jul, 2007)
  • [논문] 추영국, 곽동훈, 김선미, 정지영, 이대훈, 이서울, 정규용, 도수일, 김성민, Differential expression of gangliosides in the ovary and uterus of streptozotocin-induced and db/db diabetic mice , Archives of pharmacal Research , Vol.29 , No.8 , pp.666 -676 (Apr, 2006)
  • [논문] 추영국, 박용일, 곽동훈, 김선미, 최한길, 김지수, 이대훈, 이서울, 정규영, 주운진, 도수일, 김성민, Pathophysiological Implication of Ganglioside GM3 in Early Mouse Embryonic Development through Apoptosis , Archives of Pharmacal Research , Vol.28 , No.9 , pp.1057 -1064 (Oct, 2005)
  • [논문] 도수일, 손경철, Transcriptional regulation and O-GlcNAcylation activity of zebrafish OGT during embryogenesis , ELSEVIER Inc. (USA) , Vol.337 , pp.256 -263 (Sep, 2005)
  • [논문] 도수일, 박재은, 손경철, 이기영, OGT functions as a catalytic chaperone under heat stress response:a unique defense role of OGT in hyperthermia , Biochemical and Biophysical Research Communications , Vol.322 , No.3 , pp.1045 -1051 (Aug, 2004)
국내학술논문지
  • [논문] Young Il Park, Yoon Hee Lee, Sung Min Kim, Sung Oog Kim, Young Kug Choo, 도수일, Jae Kweon Park, O-GlcNAcylation of proteins and UDP-GlcNAc content in rat brain cortex tissue change during early post-natal development , Journal of Chitin and Chitosan , Vol.14 , No.4 , pp.214 -219 (Dec, 2009)
  • [논문] 이상수, 박재은, 이기성, 도수일, A mutagenic study of beta-1,4-galactosyltransferases from Neisseria meningitidis , Journal of Biochemistry and Molecular Biology , Vol.37 , No.5 , pp.597 -602 (Sep, 2004)
국제학술발표
  • [학술회의] 도수일, Biological significance for the Cys S-nitrosylation of OGT , International Symposium on Glycoconjugates, Glyco 24th , Vol.23 , No.110 , pp.89 -89 (Aug, 2017)
  • [학술회의] 도수일, 이영춘, 추영국 , 박용일, 유인현, 신일수, Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innated immune response , 2012 KSBMB (Korean Society for Biochemistry and Molecular Biology) ANNUAL Meeting , pp.160 -160 (May, 2012)
  • [학술회의] Yong Il Park, Sung Min Kim, Hye Ran Moon, Mi Ja Chung, Myung Hoon Chun, Seong Yun Kim, Young Kug Choo, 도수일, Tae Joung Ha, Effect of Black Soyean Anthocyanin on the Alteration of α2,3-Sialiytransferases Gene Expression during Hydrogen Peroxide-Induced Cell Death , Asian Communications of Glycobiology and Glycotechnology Conference , Vol.1 , No.52 , pp.52 -52 (Oct, 2010)
  • [학술회의] Yong Il Park, Ha Na, Choi, Yoon Hee Lee, Young Choon Lee, Young Kug Choo, 도수일, Sung Min Kim, Changes in α-2,3 Sialylation of Glycoprotein Carbohydrate during Glucose Deprivation of Neuron cells , Asian Communications of Glycobiology and Glycotechnology Conference , Vol.1 , No.51 , pp.51 -51 (Oct, 2010)
  • [학술회의] Young Il Park, Ha Na Choi, Yoon Hee Lee, Hey Ran Moon, Young Kug Choo, 도수일, Doo Jin Choi, alpha-2,3 sialylation on neurobnal cell surfcae N-glycans increases during glucose deprivation , 한국당과학회하계학술대회 , Vol.1 , No.1 , pp.1 -2 (Jun, 2010)
  • [학술회의] 도수일, 유인현, 신일수, Sp1 mediated regulation for target protein recognition of ncOGT , 2009 KSG International Glycoscience Symposium , Vol.1 , No.1 , pp.61 -61 (Nov, 2009)
  • [학술회의] 도수일, 신일수, 유인현, 손경철, Differential transcriptional variants of zebrafish OGT are generated by alternative splicing during embryogenesis , 2009 KSG International Glycoscience Symposium , Vol.1 , No.1 , pp.62 -62 (Nov, 2009)
  • [학술회의] 도수일, 유인현, Chimeric lacdiNac syntesizing glycosyltransferase , 2009 KSG International Glycoscience Symposium , Vol.1 , No.1 , pp.60 -60 (Nov, 2009)
  • [학술회의] Y.I.Park, Y.H.Lee, S.M.Kim, 도수일, Y.K.Choo, Decreased in alpha2,3 and alpha2,6-sialylation in rat brain cortex tissue during early post-natal development correlates with increased sialidase activity , 2008 Eastern Asian Glycoscience Symposium , Vol.1 , No.31 , pp.90 -91 (Nov, 2008)
  • [학술회의] 도수일, LacNAc and LacdiNAc Glycoconjugates , 2008년춘계당과학회국제심포지움 , Vol.1 , No.1 , pp.1 -1 (Jun, 2008)
  • [학술회의] Y.I.park, Y.K.Choo, Y.H.Lee, S.M.Kim, W.J.Kim, 도수일, H.G.Kim, alpha2,6 and alpha2,3-ㅣlinked sialyltation of glycoproteins in rat brain cortex tissue change during early postnatal development , PepCon-2008 From Concept to Market , Vol.1 , No.1 , pp.1 -1 (Apr, 2008)
  • [학술회의] Y.I.Park, Y.H.Lee, S.M.Kim, W.J.Kim, 도수일, Y.K.Choo, Increased alpha2,3-sialylation and hyperglycosylation in glycoproteins of the primary cultured prenatal rat cortical neuron cells occur during camptothecin-induced apoptosis , PepCon-2008 From Concept to Market , Vol.1 , No.1 , pp.267 -267 (Apr, 2008)
  • [학술회의] YI Park, YK Choo, YC Lee, YH Lee, 도수일, SM Kim, alpha2,3- and alpha2,6-sialylation on glycoproteins of rat brain cortex trssues change with development and aging , 한국당과학회2007년 연례학술대회 국제심포지움 , Vol.1 , No.1 , pp.1 -2 (Nov, 2007)
  • [학술회의] 박용일, 추영국, 이윤희, 이정선, 도수일, 김성민, Differential expression of cell surface sialo-glycoconjugates during the camptothecin-induced apoptosis of embryonic rat brain cortical neuron cells , 63rd KSBMB Annual Meeting , pp.369 -370 (May, 2006)
  • [학술회의] 주은진, 곽동훈, 김성민, 주영국, 이대훈, 이서의, 정규용, 도수일, 박용일, Differential distribution of ganglioside GM3 during apoptosis in preimplantation mouse embryos , 제4회 발생공학 국제심포지움 및 학술대회 , pp.106 (Oct, 2004)
  • [학술회의] 도수일, Sialyltransferase inhibitors in mammalian cells , The 61th Annual Meeting 2004 From Molecules to Systems , pp.13 (May, 2004)
국내학술발표
  • [학술회의] 박용일, 추영국, 이윤희, 이정선, 도수일, Cheng Min Jin, Surface sialo-glycoconjugates change during the apoptosis of embryonic rat cortical neuron cells , 2006 1st Annual Meeting of Korean Society for Glycoscience , pp.53 -54 (Nov, 2006)
  • [학술회의] 도수일, OGT and O-GlcNAc, old and new story , 2006 한국당과학회 제1회 연례학술대회 , pp.8 -8 (Nov, 2006)
  • [학술회의] 도수일, Novel chaperone function of OGT-mediated protein O-GlcNAcylation , 생체복합당질 구조-기능 심포지움 , pp.6 (Dec, 2004)
저서 및 번역
  • [저서] 홍영남, 김혜선, 남석현, 도수일, 문은표, 민철기, 박상규, 이종수, 최상돈, 강혜순, 고영규, 고용, 권윤의, 김기중, 김영환, 김은수, 김재진, 김정국, 김준, 박선우, 박세호, 박용근, 박우준, 신숙, 신정섭, 안지훈, 안태인, 오승은, 이경호, 이명민, 이봉희, 이태호, 이호정, 장태용, 조면행, 조진원, 이상임, 김한집, 생명과학 (Mar, 2009)
특허 및 기타
  • [특허] 도수일, SNO-OGT 억제제를 포함하는 알츠하이머병, 퇴행성 뇌질환 예방 또는 치료용 약학적 조성물 (등록) (10-1723514) (Mar, 2017)
  • [특허] 문은표, 도수일, 최재혁, 김재호, 식물병원성 세균에 대한 항미생물 펩티드 KCM11 (등록) (10-0915852) (Aug, 2009)
  • [특허] 문은표, 도수일, 최재혁, 김재호, 식물병원성 세균에 대한 항미생물 펩티드 KCM12 (등록) (10-0915855) (Aug, 2009)
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