교수진

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교수진소개

교수정보의 상세 화면
도수일
이름
도수일
학력
박사
전공
생명과학전공(과)
정보
연구실 :
원천관133호

연구실번호 :
2548

이메일 :
sido@ajou.ac.kr

연구관심분야 :
알츠하이머 및 선천면역 관련 당단백질 구조 및 기능, 당생물학

홈페이지 :
학력
졸업연도/학교/학위
1992.07 Univ. of Georgia, Athens 박사
연구분야 본 연구실은 포유류 글라이코믹스(Mammalian cell glycomics) 실험을 진행하고 있는 Functional Glycomics 실험실로서 세포수준 및 분자수준에서 당단백질 Glycoproteins 및 복합당질 Glycoconjugates 의 다양한 기능과 구조를 규명하는 최신연구들을 수행하고 있다. 특별히 인체 선천면역 방어기전에 관련된 당단백질의 기능해석과 암질환 및 알츠하이머와 같은 뇌신경질환에서 당단백질의 작용기전을 규명하고 있다.
DNA와 RNA를 분석하는 분자생물학기술은 물론 PCR 증폭, 동물세포 배양, HPLC 분석, 당단백질 전기영동 및 Western blotting등 다양한 생물학적, 생화학적 기법을 이용하여 인체질환과 관련된 핵심적인 복합당질 분석 및 당단백질 작용점을 분석하는 실험들을 진행하고 있다. 또한 인체질환 관련 당단백질 작용점에 대한 작용기전의 규명을 위해 동물을 이용한 in vivo 준 임상실험도 병행해서 수행하고 있으며 최종 당단백질 작용점을 타겟하는 당의약(Glyco-Drug) 개발을 위한 당의과학 실험을 진행하고 있다.
논문 및 연구활동
연구활동(주요논문)
  • [논문] Untamed aspects of OGT and O-GlcNAc functionality: Hyperthermal sensing and NO regulation (Trends in comparative biochemistry and physiology) - 2012.12
    도수일
  • [논문] Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids (Life Sciences) - 2012.06
    박용일, 추영국, Kim SM, Chun MH, Ha TJ, Choi HN, Jang SJ, Kim SO, 도수일, Chung MJ
  • [논문] Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS) - 2011.04
    도수일, 유인현
  • [논문] Selective alpha-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties (BIOORGANIC & MEDICINAL CHEMISTRY LETTERS) - 2011.02
    유재훈, 현순실, 도수일, 박상은
  • [논문] Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells (EXPERIMENTAL AND MOLECULAR MEDICINE) - 2010.12
    Young-Choon Lee, Haw-Young Kwon, Seok-Jo Kim, Sung-Wook Son, Kyoung-Sook Kim, Jai-Heon Lee, 도수일, Cheorl-Ho Kim
국제학술논문지
  • [논문] Untamed aspects of OGT and O-GlcNAc functionality: Hyperthermal sensing and NO regulation (Trends in comparative biochemistry and physiology) - 2012.12
    도수일
  • [논문] Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1-JNK/p38 pathways and mobilization of cellular sialic acids (Life Sciences) - 2012.06
    박용일, 추영국, Kim SM, Chun MH, Ha TJ, Choi HN, Jang SJ, Kim SO, 도수일, Chung MJ
  • [논문] Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response (BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS) - 2011.04
    도수일, 유인현
  • [논문] Selective alpha-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties (BIOORGANIC & MEDICINAL CHEMISTRY LETTERS) - 2011.02
    유재훈, 현순실, 도수일, 박상은
  • [논문] Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells (EXPERIMENTAL AND MOLECULAR MEDICINE) - 2010.12
    Young-Choon Lee, Haw-Young Kwon, Seok-Jo Kim, Sung-Wook Son, Kyoung-Sook Kim, Jai-Heon Lee, 도수일, Cheorl-Ho Kim
  • [논문] Generation of novel chimeric LacdiNAcS by gene fusion of alpha-lactalbumin and beta1,4-galactosyltransferase 1 (Glycoconjugate Journal) - 2008.11
    도수일
  • [논문] Valproic acid-mediated transcriptional regulation of human GM3 synthase (hST3Gal V) in SK-N-BE(2)-C human neuroblastoma cells (Acta Phamacologica Sinica) - 2008.09
    Y.C.Lee, C.H.Kim, N.Y.Kang, H.M.Dae, H.Y.Kwon, 도수일, K.S.Kim
  • [논문] Sp1 modulates ncOGT activity to alter target recognition and enhanced thermotolerance in E. coli (Biochemical and Biophysical Research Communication) - 2008.05
    도수일, 유인현, 신일수
  • [논문] Increased alpha-2,3-sialylation and hyperglycosylation of N-glycans in embryomic rat cortical neurons during camptothecin-induced apoptosis (Molecules and Cells) - 2007.12
    YI Park, SM Kim, YK Choo, WJ Kim, YH Lee, 도수일, JS Lee
  • [논문] Effects of daunorubicin on ganglioside expression and neuronal differentiation of mouse embryonic stem cells (Biochemical and Biophysical Research Communication) - 2007.08
    YJ Choo, DH Lee, DB Koo, HJ Yang, SM Kim, JU Jung, JW Jin, KN Ko, KS Ko, KY Jung, 도수일, JS Ryu
  • [논문] Bi-functional activities of chimeric lysozymes constructed by domain swapping between bacteriophage T7 and K11 lysozymes (Journal of Biochemistry and Molecular Biology) - 2007.07
    SS Lee, EH Alcantara외, DH Kim, 도수일
  • [논문] Differential expression of gangliosides in the ovary and uterus of streptozotocin-induced and db/db diabetic mice (Archives of pharmacal Research) - 2006.04
    추영국, 곽동훈, 김선미, 정지영, 이대훈, 이서울, 정규용, 도수일, 김성민
  • [논문] Pathophysiological Implication of Ganglioside GM3 in Early Mouse Embryonic Development through Apoptosis (Archives of Pharmacal Research) - 2005.10
    추영국, 박용일, 곽동훈, 김선미, 최한길, 김지수, 이대훈, 이서울, 정규영, 주운진, 도수일, 김성민
  • [논문] Transcriptional regulation and O-GlcNAcylation activity of zebrafish OGT during embryogenesis (ELSEVIER Inc. (USA)) - 2005.09
    도수일, 손경철
  • [논문] OGT functions as a catalytic chaperone under heat stress response:a unique defense role of OGT in hyperthermia (Biochemical and Biophysical Research Communications) - 2004.08
    도수일, 박재은, 손경철, 이기영
국내학술논문지
  • [논문] O-GlcNAcylation of proteins and UDP-GlcNAc content in rat brain cortex tissue change during early post-natal development (Journal of Chitin and Chitosan) - 2009.12
    Young Il Park, Yoon Hee Lee, Sung Min Kim, Sung Oog Kim, Young Kug Choo, 도수일, Jae Kweon Park
  • [논문] A mutagenic study of beta-1,4-galactosyltransferases from Neisseria meningitidis (Journal of Biochemistry and Molecular Biology) - 2004.09
    이상수, 박재은, 이기성, 도수일
국제학술발표
  • [학술회의] Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innated immune response (2012 KSBMB (Korean Society for Biochemistry and Molecular Biology) ANNUAL Meeting) - 2012.05
    도수일, 이영춘, 추영국 , 박용일, 유인현, 신일수
  • [학술회의] Changes in α-2,3 Sialylation of Glycoprotein Carbohydrate during Glucose Deprivation of Neuron cells (Asian Communications of Glycobiology and Glycotechnology Conference) - 2010.10
    Yong Il Park, Ha Na, Choi, Yoon Hee Lee, Young Choon Lee, Young Kug Choo, 도수일, Sung Min Kim
  • [학술회의] Effect of Black Soyean Anthocyanin on the Alteration of α2,3-Sialiytransferases Gene Expression during Hydrogen Peroxide-Induced Cell Death (Asian Communications of Glycobiology and Glycotechnology Conference) - 2010.10
    Yong Il Park, Sung Min Kim, Hye Ran Moon, Mi Ja Chung, Myung Hoon Chun, Seong Yun Kim, Young Kug Choo, 도수일, Tae Joung Ha
  • [학술회의] alpha-2,3 sialylation on neurobnal cell surfcae N-glycans increases during glucose deprivation (한국당과학회하계학술대회) - 2010.06
    Young Il Park, Ha Na Choi, Yoon Hee Lee, Hey Ran Moon, Young Kug Choo, 도수일, Doo Jin Choi
  • [학술회의] Sp1 mediated regulation for target protein recognition of ncOGT (2009 KSG International Glycoscience Symposium) - 2009.11
    도수일, 유인현, 신일수
  • [학술회의] Differential transcriptional variants of zebrafish OGT are generated by alternative splicing during embryogenesis (2009 KSG International Glycoscience Symposium) - 2009.11
    도수일, 신일수, 유인현, 손경철
  • [학술회의] Chimeric lacdiNac syntesizing glycosyltransferase (2009 KSG International Glycoscience Symposium) - 2009.11
    도수일, 유인현
  • [학술회의] Decreased in alpha2,3 and alpha2,6-sialylation in rat brain cortex tissue during early post-natal development correlates with increased sialidase activity (2008 Eastern Asian Glycoscience Symposium) - 2008.11
    Y.I.Park, Y.H.Lee, S.M.Kim, 도수일, Y.K.Choo
  • [학술회의] LacNAc and LacdiNAc Glycoconjugates (2008년춘계당과학회국제심포지움) - 2008.06
    도수일
  • [학술회의] alpha2,6 and alpha2,3-ㅣlinked sialyltation of glycoproteins in rat brain cortex tissue change during early postnatal development (PepCon-2008 From Concept to Market) - 2008.04
    Y.I.park, Y.K.Choo, Y.H.Lee, S.M.Kim, W.J.Kim, 도수일, H.G.Kim
  • [학술회의] Increased alpha2,3-sialylation and hyperglycosylation in glycoproteins of the primary cultured prenatal rat cortical neuron cells occur during camptothecin-induced apoptosis (PepCon-2008 From Concept to Market) - 2008.04
    Y.I.Park, Y.H.Lee, S.M.Kim, W.J.Kim, 도수일, Y.K.Choo
  • [학술회의] alpha2,3- and alpha2,6-sialylation on glycoproteins of rat brain cortex trssues change with development and aging (한국당과학회2007년 연례학술대회 국제심포지움) - 2007.11
    YI Park, YK Choo, YC Lee, YH Lee, 도수일, SM Kim
  • [학술회의] Differential expression of cell surface sialo-glycoconjugates during the camptothecin-induced apoptosis of embryonic rat brain cortical neuron cells (63rd KSBMB Annual Meeting) - 2006.05
    박용일, 추영국, 이윤희, 이정선, 도수일, 김성민
  • [학술회의] Differential distribution of ganglioside GM3 during apoptosis in preimplantation mouse embryos (제4회 발생공학 국제심포지움 및 학술대회) - 2004.10
    주은진, 곽동훈, 김성민, 주영국, 이대훈, 이서의, 정규용, 도수일, 박용일
  • [학술회의] Sialyltransferase inhibitors in mammalian cells (The 61th Annual Meeting 2004 From Molecules to Systems) - 2004.05
    도수일
국내학술발표
  • [학술회의] Surface sialo-glycoconjugates change during the apoptosis of embryonic rat cortical neuron cells (2006 1st Annual Meeting of Korean Society for Glycoscience) - 2006.11
    박용일, 추영국, 이윤희, 이정선, 도수일, Cheng Min Jin
  • [학술회의] OGT and O-GlcNAc, old and new story (2006 한국당과학회 제1회 연례학술대회) - 2006.11
    도수일
  • [학술회의] Novel chaperone function of OGT-mediated protein O-GlcNAcylation (생체복합당질 구조-기능 심포지움) - 2004.12
    도수일
저서 및 번역
  • [저서] 생명과학 - 2009.03
    홍영남, 김혜선, 남석현, 도수일, 문은표, 민철기, 박상규, 이종수, 최상돈, 강혜순, 고영규, 고용, 권윤의, 김기중, 김영환, 김은수, 김재진, 김정국, 김준, 박선우, 박세호, 박용근, 박우준, 신숙, 신정섭, 안지훈, 안태인, 오승은, 이경호, 이명민, 이봉희, 이태호, 이호정, 장태용, 조면행, 조진원, 이상임, 김한집
특허 및 기타
  • [특허] 식물병원성 세균에 대한 항미생물 펩티드 KCM12 (등록) (10-0915855) - 2009.08
    문은표, 도수일, 최재혁, 김재호
  • [특허] 식물병원성 세균에 대한 항미생물 펩티드 KCM11 (등록) (10-0915852) - 2009.08
    문은표, 도수일, 최재혁, 김재호
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